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KMID : 0043319880110030250
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Archives of Pharmacal Research
1988 Volume.11 No. 3 p.250 ~ p.252
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A Sensitive and Simplified HPLC Analysis for the Determination of Fluconazol in Human Plasma
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Kim EJ
Lee HS/Zee OP/Lee ST
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Abstract
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A sensitive and simplified HPLC assay of fluconazol is described. The calibration curve of fluconazol in plasma ranging 0-10mcg/ml was linear with the correlation coefficients of 0.9900. The limit of detection was 0.3mcg/ml. The average recovery of the drug was 89.1 +/- 9.05%. After oral administration of single dose(150mg) of fluconazol in man, Cmax and Tmax were 3mcg/ml and 4hr., respectively.
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KEYWORD
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